Marcelo G Kazanietz Selected Research

Phorbol Esters

1/2020	Identification of a truncated β1-chimaerin variant that inactivates nuclear Rac1.
1/2019	Distinctive requirement of PKCε in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells.
1/2019	Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes.
1/2018	Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.
1/2017	Protein kinase C in cancer: The top five unanswered questions.
1/2013	Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes.
1/2012	Contribution of individual PKC isoforms to breast cancer progression.
4/2011	Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis.
9/2010	Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha.
8/2010	Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway.

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Marcelo G Kazanietz Research Topics

Disease

49	Neoplasms (Cancer) 12/2022 - 05/2003
21	Prostatic Neoplasms (Prostate Cancer) 10/2020 - 01/2002
20	Breast Neoplasms (Breast Cancer) 01/2019 - 10/2002
16	Neoplasm Metastasis (Metastasis) 12/2022 - 05/2003
12	Carcinogenesis 12/2020 - 07/2004
9	Lung Neoplasms (Lung Cancer) 11/2021 - 01/2008
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 02/2008
3	Pancreatic Neoplasms (Pancreatic Cancer) 10/2020 - 01/2010
2	Adenocarcinoma of Lung 11/2021 - 10/2005
2	Severe Acute Respiratory Syndrome 10/2021 - 07/2021
2	Coronavirus Infections 10/2021 - 07/2021
2	COVID-19 10/2021 - 07/2021
2	Carcinoma (Carcinomatosis) 03/2007 - 05/2003
1	Colorectal Neoplasms (Colorectal Cancer) 12/2019
1	Autoimmune Diseases (Autoimmune Disease) 01/2019
1	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 01/2019
1	Disease Progression 06/2018
1	Adenocarcinoma 01/2018
1	Colonic Neoplasms (Colon Cancer) 01/2018
1	Hypoxia (Hypoxemia) 01/2016

Drug/Important Bio-Agent (IBA)

23	Protein Kinase CIBA 01/2019 - 01/2002
19	Phorbol EstersIBA 01/2020 - 01/2002
15	IsoenzymesIBA 01/2019 - 10/2002
12	Monomeric GTP-Binding ProteinsIBA 11/2021 - 02/2008
10	Phosphotransferases (Kinase)IBA 12/2022 - 12/2005
10	AndrogensIBA 02/2020 - 01/2002
9	DiglyceridesIBA 12/2022 - 01/2002
9	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2019 - 07/2004
8	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 11/2021 - 02/2012
7	Proteins (Proteins, Gene)FDA Link 10/2020 - 12/2006
7	LigandsIBA 06/2018 - 11/2005
7	ErbB Receptors (EGF Receptor)IBA 01/2018 - 02/2006
6	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2021 - 07/2005
6	phorbolIBA 01/2019 - 10/2005
6	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 10/2017 - 02/2006
5	Protein Kinase C-epsilonIBA 01/2021 - 01/2012
5	Phenobarbital (Luminal)FDA Link 06/2018 - 02/2012
5	Protein Kinases (Protein Kinase)IBA 01/2018 - 11/2003
4	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 11/2021 - 12/2010
4	GTP Phosphohydrolases (GTPases)IBA 10/2020 - 10/2012
4	Neuregulin-1 (Neuregulin 1)IBA 06/2018 - 05/2013
4	Epidermal Growth Factor (EGF)IBA 06/2018 - 02/2006
4	histidine-rich proteinsIBA 08/2016 - 02/2006
4	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2013 - 05/2007
3	CarcinogensIBA 12/2020 - 01/2017
3	Guanosine Triphosphate (GTP)IBA 10/2020 - 07/2005
3	Transcription Factors (Transcription Factor)IBA 12/2019 - 01/2016
3	Messenger RNA (mRNA)IBA 01/2019 - 12/2006
3	Cyclin D1IBA 06/2018 - 07/2005
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2018 - 01/2016
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2018 - 02/2012
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2012 - 08/2010
3	beta-chimaerinIBA 09/2009 - 05/2003
2	VimentinIBA 01/2022 - 10/2020
2	LithiumIBA 10/2021 - 07/2021
2	Nucleocapsid ProteinsIBA 10/2021 - 07/2021
2	Glycogen Synthase Kinase 3IBA 10/2021 - 07/2021
2	Peptide Hydrolases (Proteases)FDA Link 12/2020 - 01/2020
2	Biological ProductsIBA 12/2020 - 04/2013
2	Benzo(a)pyreneIBA 12/2020 - 03/2007
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2018
2	Protein Isoforms (Isoforms)IBA 01/2020 - 01/2012
2	LactonesIBA 01/2019 - 01/2002
2	Small Interfering RNA (siRNA)IBA 06/2018 - 09/2015
2	CytokinesIBA 09/2015 - 10/2012
2	Antineoplastic Agents (Antineoplastics)IBA 05/2013 - 09/2010
2	rho-Associated KinasesIBA 05/2013 - 10/2009
2	Estrogen ReceptorsIBA 02/2012 - 11/2003
2	Protein Kinase C-deltaIBA 01/2010 - 11/2005
2	Androgen Receptors (Androgen Receptor)IBA 03/2009 - 12/2006
2	p38 Mitogen-Activated Protein KinasesIBA 03/2009 - 09/2003
2	heregulin beta1IBA 02/2008 - 02/2006
2	Mitogen-Activated Protein KinasesIBA 01/2005 - 11/2003
1	Type C PhospholipasesIBA 12/2022
1	EnzymesIBA 12/2022
1	Antiviral Agents (Antivirals)IBA 07/2021
1	Glycogen Synthase (Synthase I)IBA 07/2021
1	RNA (Ribonucleic Acid)IBA 12/2020
1	Guanosine Diphosphate (GDP)IBA 10/2020
1	CalciumIBA 02/2020
1	MicroRNAs (MicroRNA)IBA 12/2019
1	Myristic Acid (Tetradecanoic Acid)IBA 01/2019
1	Acetates (Acetic Acid Esters)FDA Link 01/2019
1	Chemotactic FactorsIBA 01/2019
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2019
1	ChemokinesIBA 01/2019
1	Insulin-Like Growth Factor I (IGF-1)IBA 06/2018
1	Pharmaceutical PreparationsIBA 01/2018
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2018
1	Dinoprostone (PGE2)FDA Link 01/2018
1	Caspase 3 (Caspase-3)IBA 01/2018
1	Ribosomal RNAIBA 01/2017
1	Rho Guanine Nucleotide Exchange FactorsIBA 01/2017
1	Matrix Metalloproteinase 10 (Stromelysin 2)IBA 08/2016
1	NucleotidesIBA 08/2016
1	Indicators and Reagents (Reagents)IBA 01/2016
1	Tyrosine Kinase InhibitorsIBA 05/2015
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 05/2015

Therapy/Procedure

15	Therapeutics 12/2022 - 07/2004
1	Immunotherapy 12/2022